Donna Karan essays

Donna Karan essays As quoted from Beauty Buzz website Donna Karan expresses herself as follows. Everything I do is a matter of heart, body and soul. For me, designing is a personal expression of who I am- wife, mother, artist and business person, the many roles that women everywhere are trying to balance. But before I can be anything else, Im a woman, with all the complications, feelings and emotions. This quote sums up what Donna Karan is perceived as, as well as, what she views herself as. This perception has been molded through years of obstacles and success. The following illustrates her victory through ups and downs. Donna Karan was born on October 2, 1948, in Forest Hills, New York. Her mother Helen, was a showroom model who later became a retail salesperson. She was often called, Queenie, I assume for the way she carried herself. Donnas father Gabbie, worked as a custom suit maker. Its almost as if Donnas life was pre-determined, lets face it, she had fashion influences everywhere of course she loved it. In fact, love isnt the word, she was infatuated with fashion. For example, Donna began experimenting with her very own designs and even took her passion to Liz Clairborne as an intern during the summer of her final year in high school as cited from the Angelfire website. As her love for fashion grew, Donna decided to attend The Parson School of Design in New York. That was to become her first obstacle. During that summer she managed to geta job with Anne Klein. Thus, the problem is born, co-workers convinced Donna not to go back to Parsons and continue working. She agreed only to find herself fired 9 months later. However, her connection with Anne Klein wasnt over, not even close. Sometime later Anne Klein offered Donna Karan a better position in the company, so she joined as an Associate Designer in 1971. In reality Klein depended on her very much, so much...

Antibiotics - Discovery and Resistance

Antibiotics - Discovery and Resistance Antibiotics and antimicrobial agents are drugs or chemicals that are used to kill or hinder the growth of bacteria. Antibiotics specifically target bacteria for destruction while leaving other cells of the body unharmed. Under normal conditions, our immune system is capable of handling the germs that invade the body. Certain white blood cells known as lymphocytes protect the body against cancerous cells, pathogens (bacteria, viruses, parasites), and foreign matter. They produce antibodies which bind to a specific antigen (disease causing agent) and label the antigen for destruction by other white blood cells. When our immune system gets overwhelmed, antibiotics can be useful in assisting the bodys natural defenses in controlling bacterial infections. While antibiotics have proven to be powerful antibacterial agents, they are not effective against viruses. Viruses are not independent living organisms. They infect cells and rely on the hosts cellular machinery for viral replication. Antibiotics Discovery Penicillin was the first antibiotic to be discovered. Penicillin is derived from a substance produced from molds of the Penicillium fungi. Penicillin works by disrupting bacterial cell wall assembly processes and interfering with bacterial reproduction. Alexander Fleming discovered penicillin in 1928, but it wasnt until the 1940s that antibiotic use revolutionized medical care and substantially reduced death rates and illnesses from bacterial infections. Today, other penicillin-related antibiotics including ampicillin, amoxicillin,  methicillin, and flucloxacillin are used to treat a variety of infections. Antibiotic Resistance Antibiotic resistance is becoming more and more common. Due to the prevalent use of antibiotics, resistant strains of bacteria are becoming much more difficult to treat. Antibiotic resistance has been observed in bacteria such as E.coli and MRSA. These super bugs represent a threat to public health since they are resistant to most commonly used antibiotics. Health officials warn that antibiotics should not be used to treat common colds, most sore throats, or the flu because these infections are caused by viruses. When used unnecessarily, antibiotics can lead to the spread of resistant bacteria. Some strains of Staphylococcus aureus bacteria have become resistant to antibiotics. These common bacteria infect about 30 percent of all people. In some people, S. aureus is a part of the normal group of bacteria that inhabit the body and may be found in areas such as the skin and the nasal cavities. While some staph strains are harmless, others pose serious health problems including foodborne illness, skin infections, heart disease, and meningitis. S. aureus bacteria favor the iron which is contained within the oxygen-carrying protein hemoglobin found within red blood cells. S. aureus bacteria break open blood cells to obtain the iron within the cells. Changes within some strains of S. aureus have helped them to survive antibiotic treatments. Current antibiotics work by disrupting so-called cell viability processes. Disruption of cell membrane assembly processes or DNA translation are common modes of operation for current generation antibiotics. To combat this, S. aureus have devel oped a single gene mutation that alters the organisms cell wall. This enables them to prevent breaches of the cell wall by antibiotic substances. Other antibiotic resistant bacteria, such as Streptococcus pneumoniae, produce a protein called MurM. This protein counteracts the effects of antibiotics by helping to rebuild the bacterial cell wall. Fighting Antibiotic Resistance Scientists are taking various approaches to deal with the issue of antibiotic resistance. One method focuses on interrupting the cellular processes involved in the sharing of genes among bacteria such as Streptococcus pneumoniae. These bacteria share resistant genes among themselves and can even bind to DNA in their environment and transport the DNA across the bacterial cell membrane. The new DNA containing the resistant genes is then incorporated into the bacterial cells DNA. Using antibiotics to treat this type of infection can actually induce this transfer of genes. Researchers are focusing on ways to block certain bacterial proteins to prevent the transfer of genes between bacteria. Another approach to fighting antibiotic resistance actually focuses on keeping the bacteria alive. Instead of trying to kill the resistant bacteria, scientists are looking to disarm them and make them incapable of causing infection. The intent of this approach is to keep the bacteria alive, but harmle ss. It is thought that this will help prevent the development and spread of antibiotic resistant bacteria. As scientists better understand how bacteria gain resistance to antibiotics, improved methods for treating antibiotic resistance can be developed. Learn more about antibiotics and antibiotic resistance: Scientists Target Bacterial Transfer of Resistance GenesDisarming Disease-Causing BacteriaBacteria Discovery Could Lead to Antibiotics Alternatives Sources: Centers for Disease Control and Prevention. Get Smart: Know When Antibiotics Work. Updated 05/01/12. cdc.gov/getsmart/antibiotic-use/antibiotic-resistance-faqs.html